Have you experienced sudden headache attacks accompanied by nausea and high sensitivity to light and noise? This form of headache is known as migraine and about 20% of the Russian population suffer from it. It is believed that this disease is one of the most common causes of people's disability, since in such pain a person can only lie in bed. Moreover, in some cases, it is difficult to get rid of, since drugs that work against it are contraindicated for people with cardiovascular disease. Soon, however, there will be far fewer people who suffer from severe headaches – a drug that is suitable for almost all people.
The new drug is called Urogeptant but is currently not approved by the US Food and Drug Administration (FDA). However, it was effective in three clinical trials involving 1686 participants who suffered from migraine two to eight times a month. They were assigned the task of taking Urogeptan's headache within 4 hours of the onset of the first seizures. If the medication did not help, the volunteers were allowed to drink a second tablet, and in case of complete drug inefficiency, people drank what had previously helped them.
How to get rid of a headache?
The results of the study were published in the journal JAMA. Scientists found that in 20% of subjects, the drug eliminated severe headache within two hours. After taking the second pill, more people were freed from migraine. Based on these observations, the researchers concluded that it is necessary to drink at least 50 milligrams of uropraptone to eliminate headaches.
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It is worth noting that the new drug is far from being the most effective. Since the 1990s, so-called triptans have treated migraines, which fulfill their task in 75% of cases. This class of drugs works on serotonin in the brain, whose low content is considered to be one of the causes of pain. The drug class is effective, but it narrows the blood vessels, which is why it is contraindicated in people with cardiovascular disease.
In contrast to triptans, uroproteins act on a substance called CGRP, which also plays a major role in the development and spread of severe headache. However, it does not affect the width of the vessels, so it can be taken by almost all patients. It may not work in some cases, but it's better than not having a chance to quickly get rid of the debilitating headaches that prevent you from doing important things.
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Nobody knows when the new drug will be approved and how much it will cost. At present, there are other modern anti-migraine remedies, such as Aimovig, which was developed in 2018. It also works on a substance called CGRP and has been well proven in clinical trials. Only now is the drug injected monthly in the form of regular injections, and one year of this treatment costs patients $ 6900. And by the way, that's about 400,000 rubles.